MicroElectrode Arrays Applications
The multi-channel cell/tissue monitoring approach is used to investigate system properties in excitable cell cultures and tissue slices.
Microelectrode arrays can be used with several in-vitro preparations in different culture systems. In most cases, single unit activity and/or slow field potentials are recorded in preparations such as dissociated cell cultures (neurons, heart muscle cells) and organotypic or acute tissue slices (brain, spinal cord, retina, etc.).
• Stem cell derived cell/tissue cultures (neurospheres, brain-on-a-chip, … )
• Acute tissue slices (hippocampus, cerebellum, spinal cord, retina, … )
• Dissociated cell cultures (neurons, heart muscle cells, … )
• Organotypic tissue cultures (hippocampus, cortex, spinal cord, … ) and co-cultures
Most electrophysiology monitoring experiments address questions in the following fields of study:
• Functional screening in drug discovery
• Toxicity and safety pharmacology
• Synaptic plasticity
• Neural development
• Regeneration
• Biological rhythms
• Network oscillators
Examples of different in vitro culture systems

Air-liquid interface cultures
HiPSC neurosphere on porous MEA

Acute tissue slice preparations
Rat hippocampus slice on 3D MEA

Dissociated cell cultures
Confluent layer of cardiomyocytes

Organotypic cultures
Rat spinal cord tissue slice