Micro Electrode Arrays Applications
The multi-channel cell/tissue monitoring approach is used to investigate system properties in excitable cell cultures and tissue slices.
Micro electrode arrays can be used with several in-vitro preparations in different culture systems. In most cases, single unit activity and/or slow field potentials are recorded in preparations such as dissociated cell cultures (neurons, heart muscle cells) and organotypic or acute tissue slices (brain, spinal cord, retina, etc.).
• Stem cell derived cell/tissue cultures (neurospheres, brain-on-a-chip, … )
• Acute tissue slices (hippocampus, cerebellum, spinal cord, retina, … )
• Dissociated cell cultures (neurons, heart muscle cells, … )
• Organotypic tissue cultures (hippocampus, cortex, spinal cord, … ) and co-cultures
Most electrophysiology monitoring experiments address questions in the following fields of study:
• Functional screening in drug discovery
• Toxicity and safety pharmacology
• Synaptic plasticity
• Neural development
• Regeneration
• Biological rhythms
• Network oscillators
Examples of different in vitro culture systems
![hIPSC neurosphere on MEA (HEPIA) hIPSC neurosphere on MEA (HEPIA)](https://microelectrodedevices.com/wp-content/uploads/2020/09/hIPSC-neurosphere-on-MEA-HEPIA.jpg)
Air-liquid interface cultures
HiPSC neurosphere on porous MEA
![Acute rat hippocampus slice on 3D MEAAcute rat hippocampus slice on 3D MEA (MicroElectrodeDevices.com) Acute rat hippocampus slice on 3D MEA (MicroElectrodeDevices.com)](https://microelectrodedevices.com/wp-content/uploads/2020/09/Acute-rat-hippocampus-slice-on-3D-MEA.jpg)
Acute tissue slice preparations
Rat hippocampus slice on 3D MEA
![Monolayer of confluent rat cardiomyocytes on MEA (MicroElectrodeDevices.com) Monolayer of confluent rat cardiomyocytes on MEA (MicroElectrodeDevices.com)](https://microelectrodedevices.com/wp-content/uploads/2020/09/Monolayer-of-confluent-rat-cardiomyocytes-on-MEA.jpg)
Dissociated cell cultures
Confluent layer of cardiomyocytes
![Organoic culture of rat spinal cord tissue on MEA (MicroElectrodeDevices.com) Organoic culture of rat spinal cord tissue on MEA (MicroElectrodeDevices.com)](https://microelectrodedevices.com/wp-content/uploads/2020/09/Organoic-culture-of-rat-spinal-cord-tissue-on-MEA.jpg)
Organotypic cultures
Rat spinal cord tissue slice