Micro Electrode Arrays Applications

The multi-channel cell/tissue monitoring approach is used to investigate system properties in excitable cell cultures and tissue slices.

Micro electrode arrays can be used with several in-vitro preparations in different culture systems. In most cases, single unit activity and/or slow field potentials are recorded in preparations such as dissociated cell cultures (neurons, heart muscle cells) and organotypic or acute tissue slices (brain, spinal cord, retina, etc.).

• Stem cell derived cell/tissue cultures (neurospheres, brain-on-a-chip, … )
• Acute tissue slices (hippocampus, cerebellum, spinal cord, retina, … )
• Dissociated cell cultures (neurons, heart muscle cells, … )
• Organotypic tissue cultures (hippocampus, cortex, spinal cord, … ) and co-cultures

Most electrophysiology monitoring experiments address questions in the following fields of study:

• Functional screening in drug discovery
• Toxicity and safety pharmacology
• Synaptic plasticity
• Neural development
• Regeneration
• Biological rhythms
• Network oscillators

Examples of different in vitro culture systems

hIPSC neurosphere on MEA (HEPIA)

Air-liquid interface cultures

HiPSC neurosphere on porous MEA

Acute rat hippocampus slice on 3D MEA (MicroElectrodeDevices.com)

Acute tissue slice preparations

Rat hippocampus slice on 3D MEA 

Monolayer of confluent rat cardiomyocytes on MEA (MicroElectrodeDevices.com)

Dissociated cell cultures

Confluent layer of cardiomyocytes

Organoic culture of rat spinal cord tissue on MEA (MicroElectrodeDevices.com)

Organotypic cultures

Rat spinal cord tissue slice