Micro Electrode Arrays Applications

The multi-channel cell/tissue monitoring approach is used to investigate system properties in excitable cell cultures and tissue slices.

Micro electrode arrays can be used with several in-vitro preparations in different culture systems. In most cases, single unit activity and/or slow field potentials are recorded in preparations such as dissociated cell cultures (neurons, heart muscle cells) and organotypic or acute tissue slices (brain, spinal cord, retina, etc.).

• Stem cell derived cell/tissue cultures (neurospheres, brain-on-a-chip, … )
• Acute tissue slices (hippocampus, cerebellum, spinal cord, retina, … )
• Dissociated cell cultures (neurons, heart muscle cells, … )
• Organotypic tissue cultures (hippocampus, cortex, spinal cord, … ) and co-cultures

Most electrophysiology monitoring experiments address questions in the following fields of study:

• Functional screening in drug discovery
• Toxicity and safety pharmacology
• Synaptic plasticity
• Neural development
• Regeneration
• Biological rhythms
• Network oscillators

Examples of different in vitro culture systems